What is Tadalafil
Tadalafil is the active substance in the medication Cialis which is used to treat erectile dysfunction in men. Tadalafil improves circulation in the pelvic organs enhancing the blood flow in the penis. Other than erectile dysfunction, Tadalafil is used for two other conditions. It is indicated for prostatic hyperplasia and Adcirca (Tadalafil) is used for pulmonary hypertension.
Tadalafil was approved by the FDA in 2003. Recognition by the Food and Drug Agency means that Tadalafil is effective and safe.
Tadalafil Citrate mechanism of action
Tadalafil Citrate is cGMP-specific phosphodiesterase type 5 (PDE-5) inhibitor. Its action includes vessels widening that enhances the blood flow to the cavernous bodies of the penis. Filled with blood, they induce erection.
PDE-5 is found everywhere in the human body but the highest concentration is the penis, lungs, and retina.
Interaction with other drugs. Contraindications and side effects
Consult your doctor first before using Tadalafil to treat erectile dysfunction. Be aware that some medications are not compatible with Tadalafil. Be especially serious about the following symptoms and conditions.
- Allergic reaction for food and medications.
- Kidney or liver disease regardless of its severity.
- Cardiovascular diseases.
- Genetic vision disorders.
- Heart stroke in the last 3 months.
- Pain in the chest during sex.
- Your doctor recommendations to avoid sex for health reasons.
Tadalafil is incompatible with nitrates and “poppers”. Taking Tadalafil with these substances may cause a sudden and dangerous drop in the blood pressure.
Do not take Tadalafil with other PDE-5 inhibitors. For example, Avanafil, Vardenafil, and Sildenafil. Avoid taking this drug with Cialis and Adcirca as they also contain Tadalafil.
Undesirable effects may occur when you take Tadalafil with grapefruits and grapefruit juice.
Tadalafil is a safe medication and side effects do not occur frequently and typically, disappear without a medical attention. When you take the drug regularly, your body adapts and side effects stop bothering you. Of course, if side effects do not go away and spoil your life, you want to visit a doctor.
Most often, patients who take Tadalafil experience digestive problems and headache. Stuffy nose, hot flushes, coughing, and muscular pain are not so common.
Cialis side effects that require immediate medical attention
The following side effects occur rarely.
- Allergic reaction with skin redness, edema, flaky skin, rash, blisters, and itchy skin.
- Throat and facial swelling, difficulty breathing and swallowing. Loss of balance, mental confusion and difficulty in pronouncing words.
- Severe headache.
- Irregular heart rhythm, tightness and pain in the chest.
- Lightheadedness and faintness.
- Vomiting and upset stomach.
- Vision and hearing distortion, ringing in the ears.
- Shortness of breath even at rest.
- Swollen extremities.
- Hematomas or bleeding.
- Painful erection that may last for a long time (up to 4 hours).
If you noticed any of these symptoms, you should immediately visit a doctor.
Dosage and use
Tadalafil is taken according to your doctor prescription. Do not increase or decrease the dosage and do not take it for a longer period than it has been prescribed. Tadalafil should not be split or chewed – swallow whole pills.
Healthy men under 65 years old are prescribed 10 mg of Tadalafil to take before an intercourse. The dose may be adjusted depending on individual tolerance. It may be increased to 20 mg or decreased to 5 mg.
The dose for a regular use of Tadalafil is 2.5-5 mg.
It is recommended to take Tadalafil half an hour before sex. The drug remains effective for 36 hours.
Do not take Tadalafil more than once a day. It is recommended to take the drug at approximately the same time.
Tadalafil effectiveness does not depend on the meals.
A decreased dose of Tadalafil is indicated for men with kidney or liver disease. In case of severe diseases, avoid taking this drug.
Erection – after you take Tadalafil – occurs only in the presence of a sexual stimulation. The drug alone does not induce erection.
The dose of Tadalafil for benign prostatic hyperplasia is 5 mg per day.
Generic is a medication manufactured by the company B using the active substance developed by the company A to manufacture its original drug.
Drug development is, first of all, the development of a new active substance. The substance should undergo numerous tests and studies, this is a long process. Only when positive results are proved, a new drug is brought to the market and it is an original drug. The pharmaceutical company that developed the drug has an exclusive right to manufacture it. The purpose of this is to give the drug developer to cover their costs.
When the patent expires, other pharmaceutical companies may produce their medications using the same active substance. They become generics.
Tadalafil Citrate was developed by the company Elly Lilly. The name of the original drug manufactured by this company is Cialis. The patent is valid until 2020 and can be extended. If the company will not extend the patent, other companies will be able to manufacture Cialis analogs.
While the new substance is already known and has been thoroughly tested and evaluated, a generic still must be approved by the FDA. It is not easy and not cheap to bring into the market a new generic legally.
However, in developing countries especially, in India Cialis generics are manufactured without conducting any tests and regardless the patent law. They are mainly sold in these markets and virtually are not distributed to the neighboring countries. They are so popular because of the their low price and because people can buy them without a prescription.
As these medications are not tested, their safety is under a question. Typically, side effects from taking Indian generics occur more frequently and they are more pronounced.
To buy Cialis (Tadalafil) legally, you need a prescription from your doctor. Even if you buy online, you will have to provide a scanned copy of the prescription.
Generics of Cialis are sold in any online pharmacy without a prescription.
Tadalafil is second only Sildenafil. Tadalafil remains effective for 36 hours. Its effectiveness and minimum side effects make it so appealing for millions of men. Tadalafil helped millions of men in many countries. It helps men regain self-confidence and confidence in their abilities.